Drug interactions
Dronedarone + Idelalisib
Severity: Contraindicated
Dronedarone and Idelalisib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and can sharply raise dronedarone concentrations. This increases the risk of QT prolongation, bradycardia and other adverse effects.
What this interaction means in plain words
Dronedarone and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Idelalisib belongs to Oncology.
Why it happens
Strong CYP3A inhibition by idelalisib reduces dronedarone clearance.
What to do
Avoid the combination; dronedarone labeling contraindicates strong CYP3A inhibitors. Use an alternative antiarrhythmic during idelalisib therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
- Ergotamine + Idelalisib Contraindicated
Frequently asked questions
Can I take Dronedarone with Idelalisib?
MediHelp rates the interaction as contraindicated. Dronedarone and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Idelalisib is a strong CYP3A inhibitor and can sharply raise dronedarone concentrations. This increases the risk of QT prolongation, bradycardia and other adverse effects.
How serious is the interaction between Dronedarone and Idelalisib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; dronedarone labeling contraindicates strong CYP3A inhibitors. Use an alternative antiarrhythmic during idelalisib therapy.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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