藥物交互作用
Duloxetine + Methylene blue
嚴重程度: 禁忌併用
Duloxetine and Methylene blue: contraindicated interaction.
最後更新
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摘要
Methylene blue inhibits monoamine oxidase A and, together with duloxetine, can cause serious serotonin syndrome. Cases with intravenous methylene blue and serotonergic antidepressants have included severe neurological toxicity.
用白話說明這項交互作用的意義
Duloxetine and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Reversible MAO-A inhibition by methylene blue combined with serotonin reuptake inhibition by duloxetine.
處置方式
Avoid in non-emergency settings. If methylene blue is urgently needed, stop duloxetine and monitor for serotonin toxicity, resuming duloxetine 24 hours after the last methylene blue dose or after the monitoring period per labeling.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Duloxetine 的其他交互作用
常見問題
Can I take Duloxetine with Methylene blue?
MediHelp rates the interaction as contraindicated. Duloxetine and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue inhibits monoamine oxidase A and, together with duloxetine, can cause serious serotonin syndrome. Cases with intravenous methylene blue and serotonergic antidepressants have included severe neurological toxicity.
How serious is the interaction between Duloxetine and Methylene blue?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in non-emergency settings. If methylene blue is urgently needed, stop duloxetine and monitor for serotonin toxicity, resuming duloxetine 24 hours after the last methylene blue dose or after the monitoring period per labeling.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Duloxetine page.
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