藥物交互作用
Duloxetine + Isocarboxazid
嚴重程度: 禁忌併用
Duloxetine and Isocarboxazid: contraindicated interaction.
最後更新
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摘要
Isocarboxazid irreversibly inhibits both MAO-A and MAO-B, so adding duloxetine (a serotonin-noradrenaline reuptake inhibitor) can allow serotonin to accumulate excessively. Serotonin syndrome (hyperthermia, clonus, agitation, autonomic instability) can be severe or fatal.
用白話說明這項交互作用的意義
Duloxetine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Duloxetine belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
為什麼會發生
Inhibition of monoamine oxidase combined with a serotonin-noradrenaline reuptake inhibitor activity leading to excess serotonergic stimulation
處置方式
Do not co-administer. Allow at least 14 days after stopping the MAOI before starting duloxetine, and 5 days after stopping duloxetine before starting an MAOI.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Duloxetine 的其他交互作用
Isocarboxazid 的其他交互作用
常見問題
Can I take Duloxetine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Duloxetine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid irreversibly inhibits both MAO-A and MAO-B, so adding duloxetine (a serotonin-noradrenaline reuptake inhibitor) can allow serotonin to accumulate excessively. Serotonin syndrome (hyperthermia, clonus, agitation, autonomic instability) can be severe or fatal.
How serious is the interaction between Duloxetine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Allow at least 14 days after stopping the MAOI before starting duloxetine, and 5 days after stopping duloxetine before starting an MAOI.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Linezolid, Methylene blue, Phenelzine. The full list is on the Duloxetine page.
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