藥物交互作用
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil
嚴重程度: 禁忌併用
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Sildenafil: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
The cobicistat component strongly inhibits CYP3A and raises sildenafil exposure considerably. This increases the likelihood of hypotension, syncope, visual disturbances and priapism.
用白話說明這項交互作用的意義
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Cobicistat inhibits CYP3A4, decreasing the metabolism of sildenafil.
處置方式
Do not use sildenafil for pulmonary arterial hypertension with this regimen. For erectile dysfunction, cap the dose at 25 mg per 48 hours and monitor for adverse effects.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Sildenafil 的其他交互作用
常見問題
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Sildenafil?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The cobicistat component strongly inhibits CYP3A and raises sildenafil exposure considerably. This increases the likelihood of hypotension, syncope, visual disturbances and priapism.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Sildenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use sildenafil for pulmonary arterial hypertension with this regimen. For erectile dysfunction, cap the dose at 25 mg per 48 hours and monitor for adverse effects.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
