藥物交互作用
Cobicistat + Sildenafil
嚴重程度: 禁忌併用
Cobicistat and Sildenafil: contraindicated interaction.
最後更新
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摘要
Cobicistat is a strong CYP3A inhibitor that substantially increases sildenafil concentrations. This raises the risk of marked hypotension, syncope, visual effects and prolonged erection.
用白話說明這項交互作用的意義
Cobicistat and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Sildenafil belongs to Genitourinary.
為什麼會發生
Cobicistat inhibits CYP3A4, reducing sildenafil clearance and first-pass metabolism.
處置方式
Avoid the combination when sildenafil is used chronically for pulmonary arterial hypertension. For erectile dysfunction, limit sildenafil to 25 mg no more than once every 48 hours and monitor blood pressure.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Sildenafil 的其他交互作用
Cobicistat 的其他交互作用
常見問題
Can I take Cobicistat with Sildenafil?
MediHelp rates the interaction as contraindicated. Cobicistat and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat is a strong CYP3A inhibitor that substantially increases sildenafil concentrations. This raises the risk of marked hypotension, syncope, visual effects and prolonged erection.
How serious is the interaction between Cobicistat and Sildenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when sildenafil is used chronically for pulmonary arterial hypertension. For erectile dysfunction, limit sildenafil to 25 mg no more than once every 48 hours and monitor blood pressure.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Sildenafil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
