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藥物交互作用

Isosorbide mononitrate + Sildenafil

嚴重程度: 禁忌併用

Isosorbide mononitrate and Sildenafil: contraindicated interaction.

最後更新 來源: US FDA label

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Concurrent use can cause profound, potentially life‑threatening hypotension with risk of syncope and myocardial ischemia/infarction.

用白話說明這項交互作用的意義

Isosorbide mononitrate and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Isosorbide mononitrate belongs to Cardiovascular; Sildenafil belongs to Genitourinary.

證據等級: High

為什麼會發生

Additive vasodilation: organic nitrates increase NO→cGMP; sildenafil inhibits PDE5, preventing cGMP breakdown, leading to marked BP reduction.

處置方式

Do not coadminister. Avoid nitrates for at least 24 hours after sildenafil.

可向藥師詢問的問題

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Isosorbide mononitrate 與 Sildenafil 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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參考資料

常見問題

Can I take Isosorbide mononitrate with Sildenafil?

MediHelp rates the interaction as contraindicated. Isosorbide mononitrate and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Concurrent use can cause profound, potentially life‑threatening hypotension with risk of syncope and myocardial ischemia/infarction.

How serious is the interaction between Isosorbide mononitrate and Sildenafil?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Avoid nitrates for at least 24 hours after sildenafil.

What other medicines interact with Isosorbide mononitrate?

MediHelp also lists interactions of Isosorbide mononitrate with, for example, Avanafil, Riociguat, Tadalafil. The full list is on the Isosorbide mononitrate page.

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