藥物交互作用
Enalapril-hydrochlorothiazide + Protein a column
嚴重程度: 禁忌併用
Enalapril-hydrochlorothiazide and Protein a column: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Patients on ACE inhibitors undergoing apheresis with a protein A immunoadsorption column have developed anaphylactoid reactions. Bradykinin accumulates because ACE inhibition blocks its breakdown, and column treatment can further activate bradykinin-related pathways.
用白話說明這項交互作用的意義
Enalapril-hydrochlorothiazide and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
ACE inhibitors block kininase II degradation of bradykinin, which accumulates during immunoadsorption and triggers anaphylactoid reactions.
處置方式
Stop the ACE inhibitor well before the procedure (labeling advises about 72 hours) and use a non-ACE-inhibitor antihypertensive meanwhile.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Enalapril-hydrochlorothiazide 的其他交互作用
常見問題
Can I take Enalapril-hydrochlorothiazide with Protein a column?
MediHelp rates the interaction as contraindicated. Enalapril-hydrochlorothiazide and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Patients on ACE inhibitors undergoing apheresis with a protein A immunoadsorption column have developed anaphylactoid reactions. Bradykinin accumulates because ACE inhibition blocks its breakdown, and column treatment can further activate bradykinin-related pathways.
How serious is the interaction between Enalapril-hydrochlorothiazide and Protein a column?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop the ACE inhibitor well before the procedure (labeling advises about 72 hours) and use a non-ACE-inhibitor antihypertensive meanwhile.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Enalapril-hydrochlorothiazide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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