藥物交互作用
Enalapril-hydrochlorothiazide + Sacubitril / valsartan
嚴重程度: 禁忌併用
Enalapril-hydrochlorothiazide and Sacubitril / valsartan: contraindicated interaction.
最後更新
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摘要
Combining an ACE inhibitor with sacubitril/valsartan markedly raises the risk of angioedema due to reduced bradykinin breakdown. Additive hypotension, hyperkalemia and renal effects from RAS blockade also occur.
用白話說明這項交互作用的意義
Enalapril-hydrochlorothiazide and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Concurrent inhibition of neprilysin and ACE reduces bradykinin degradation, causing bradykinin-mediated angioedema.
處置方式
Do not coadminister; separate by at least 36 hours when switching in either direction.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Enalapril-hydrochlorothiazide 的其他交互作用
常見問題
Can I take Enalapril-hydrochlorothiazide with Sacubitril / valsartan?
MediHelp rates the interaction as contraindicated. Enalapril-hydrochlorothiazide and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an ACE inhibitor with sacubitril/valsartan markedly raises the risk of angioedema due to reduced bradykinin breakdown. Additive hypotension, hyperkalemia and renal effects from RAS blockade also occur.
How serious is the interaction between Enalapril-hydrochlorothiazide and Sacubitril / valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; separate by at least 36 hours when switching in either direction.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
