藥物交互作用
Azathioprine + Enalapril-hydrochlorothiazide
嚴重程度: 嚴重
Azathioprine and Enalapril-hydrochlorothiazide: major interaction.
最後更新
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摘要
ACE inhibitors given with azathioprine have been associated with anemia and leukopenia, particularly in renal impairment or transplant recipients. The effect can be significant and may require dose reduction or discontinuation of one drug.
用白話說明這項交互作用的意義
Azathioprine and Enalapril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
為什麼會發生
ACE inhibitors may reduce erythropoietin and bone marrow response, adding to azathioprine myelosuppression; mechanism not fully established.
處置方式
Monitor complete blood counts regularly, especially during initiation. Reduce or stop azathioprine if cytopenias develop.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Enalapril-hydrochlorothiazide 的其他交互作用
Azathioprine 的其他交互作用
常見問題
Can I take Azathioprine with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as major. Azathioprine and Enalapril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. ACE inhibitors given with azathioprine have been associated with anemia and leukopenia, particularly in renal impairment or transplant recipients. The effect can be significant and may require dose reduction or discontinuation of one drug.
How serious is the interaction between Azathioprine and Enalapril-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly, especially during initiation. Reduce or stop azathioprine if cytopenias develop.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
