藥物交互作用
Enzalutamide + Erdafitinib
嚴重程度: 嚴重
Enzalutamide and Erdafitinib: major interaction.
最後更新
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摘要
Enzalutamide is a strong CYP3A4 inducer and also induces CYP2C9. Erdafitinib is cleared by CYP2C9 and CYP3A4, so exposure may fall and its antitumor effect may be reduced.
用白話說明這項交互作用的意義
Enzalutamide and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Erdafitinib belongs to Oncology.
為什麼會發生
Induction of CYP3A4 and CYP2C9 by enzalutamide increases erdafitinib clearance.
處置方式
Avoid coadministration where possible and consider an alternative to enzalutamide. If unavoidable, monitor serum phosphate and treatment response, as erdafitinib dosing is guided by phosphate and tolerability.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Enzalutamide 的其他交互作用
Erdafitinib 的其他交互作用
常見問題
Can I take Enzalutamide with Erdafitinib?
MediHelp rates the interaction as major. Enzalutamide and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide is a strong CYP3A4 inducer and also induces CYP2C9. Erdafitinib is cleared by CYP2C9 and CYP3A4, so exposure may fall and its antitumor effect may be reduced.
How serious is the interaction between Enzalutamide and Erdafitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible and consider an alternative to enzalutamide. If unavoidable, monitor serum phosphate and treatment response, as erdafitinib dosing is guided by phosphate and tolerability.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
