Drug interactions
Enzalutamide + Erdafitinib
Severity: Major
Enzalutamide and Erdafitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and also induces CYP2C9. Erdafitinib is cleared by CYP2C9 and CYP3A4, so exposure may fall and its antitumor effect may be reduced.
What this interaction means in plain words
Enzalutamide and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Erdafitinib belongs to Oncology.
Why it happens
Induction of CYP3A4 and CYP2C9 by enzalutamide increases erdafitinib clearance.
What to do
Avoid coadministration where possible and consider an alternative to enzalutamide. If unavoidable, monitor serum phosphate and treatment response, as erdafitinib dosing is guided by phosphate and tolerability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Enzalutamide with Erdafitinib?
MediHelp rates the interaction as major. Enzalutamide and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide is a strong CYP3A4 inducer and also induces CYP2C9. Erdafitinib is cleared by CYP2C9 and CYP3A4, so exposure may fall and its antitumor effect may be reduced.
How serious is the interaction between Enzalutamide and Erdafitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible and consider an alternative to enzalutamide. If unavoidable, monitor serum phosphate and treatment response, as erdafitinib dosing is guided by phosphate and tolerability.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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