藥物交互作用
Enzalutamide + Netupitant-palonosetron
嚴重程度: 嚴重
Enzalutamide and Netupitant-palonosetron: major interaction.
最後更新
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摘要
Enzalutamide is a strong CYP3A4 inducer and is expected to substantially lower netupitant concentrations. This may lead to reduced prevention of chemotherapy-induced nausea and vomiting. The effect can persist after enzalutamide is stopped.
用白話說明這項交互作用的意義
Enzalutamide and Netupitant-palonosetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Netupitant-palonosetron belongs to Gastrointestinal Tract.
為什麼會發生
Strong CYP3A4 induction by enzalutamide increases netupitant metabolism.
處置方式
Avoid the fixed combination and choose an antiemetic regimen not dependent on CYP3A4 exposure. If used, monitor closely for breakthrough emesis.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Netupitant-palonosetron 的其他交互作用
Enzalutamide 的其他交互作用
常見問題
Can I take Enzalutamide with Netupitant-palonosetron?
MediHelp rates the interaction as major. Enzalutamide and Netupitant-palonosetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide is a strong CYP3A4 inducer and is expected to substantially lower netupitant concentrations. This may lead to reduced prevention of chemotherapy-induced nausea and vomiting. The effect can persist after enzalutamide is stopped.
How serious is the interaction between Enzalutamide and Netupitant-palonosetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the fixed combination and choose an antiemetic regimen not dependent on CYP3A4 exposure. If used, monitor closely for breakthrough emesis.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
