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Netupitant-palonosetron

Netupitant-palonosetron is a medicine in the class gastrointestinal tract. It is used for nausea & vomiting.

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僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

重點資訊

藥物類別
Gastrointestinal Tract
常見劑型
膠囊
常見規格
300 mg, 0.5 mg
已知交互作用
165 (禁忌併用: 2 · 嚴重: 48 · 中度: 101 · 輕微: 14)
商品名
5
國家與市場
5

劑型、規格與商品名稱會因國家而異。請核對您手上的產品。

用途

作用方式

Netupitant: Tachykinin NK1 receptor (substance P) antagonist. Palonosetron: 5-hydroxytryptamine 3 (5-HT3) receptor antagonist; binds to 5-HT3 receptors both in peripheral and central nervous system, with primary effects in GI tract.

成人常用劑量（仿單摘要）

Highly emetogenic chemotherapy: 1 capsule (300 mg/0.5 mg) PO ~1 hr before starting chemotherapy OR 1 reconstituted vial (235mg/0.25mg) IV over 30 min starting 30 min before chemotherapy PLUS Dexamethasone 12 mg PO 30 minutes prior to chemotherapy on day 1 and 8 mg PO qDay on days 2-4

僅摘錄仿單中第一行劑量說明；完整的劑量內容請見 App。

懷孕與哺乳

懷孕
Unsafe No human data. Netupitant was teratogenic in rabbits with no safety margin; palonosetron alone showed no harm in animals. EU label: contraindicated in pregnancy; test for pregnancy before use and use contraception until 1 month after. Ondansetron has the most pregnancy data.
哺乳
Unknown Not known if either part passes into milk; netupitant is highly protein bound, so levels are likely low. EU label: do not breastfeed during treatment and for 1 month after. US label: weigh the benefits. LactMed: use with caution; an alternative may be preferred.

已通報的副作用

  • Headache
  • Fatigue
  • Dyspepsia
  • Asthenia

哪些人需要特別留意

  • Netupitant is a CYP3A4 substrate and a moderate inhibitor of CYP3A4.
  • Palonosetron is mainly metabolized by CYP2D6 and to a lesser extent by CYP3A4 and CYP1A2
  • Strong CYP3A4 inducers (eg, rifampin) can decrease netupitant/palonosetron efficacy by substantially reducing plasma concentrations of the netupitant component; avoid use

請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。

重要交互作用 (165)

All 165 interactions, with severity and what to do

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  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • Paediatric dosing
  • Dosing in older adults
  • Pharmacokinetics
  • Patient counselling points
  • Food interactions
  • IV preparation and dilution
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常見問題

What is Netupitant-palonosetron used for?

Netupitant-palonosetron is a medicine in the class gastrointestinal tract. It is used for Nausea & vomiting.

What side effects have been reported with Netupitant-palonosetron?

Headache, Fatigue, Dyspepsia, Asthenia.

Can Netupitant-palonosetron be taken in pregnancy or while breastfeeding?

Pregnancy: Unsafe. No human data. Netupitant was teratogenic in rabbits with no safety margin; palonosetron alone showed no harm in animals. EU label: contraindicated in pregnancy; test for pregnancy before use and use contraception until 1 month after. Ondansetron has the most pregnancy data. Breastfeeding: Unknown. Not known if either part passes into milk; netupitant is highly protein bound, so levels are likely low. EU label: do not breastfeed during treatment and for 1 month after. US label: weigh the benefits. LactMed: use with caution; an alternative may be preferred.

What does Netupitant-palonosetron interact with?

MediHelp lists 165 known interactions for Netupitant-palonosetron. Contraindicated: 2 · Major: 48 · Moderate: 101 · Minor: 14. The most serious include Apomorphine, Flibanserin, Apalutamide.

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