藥物交互作用
Apalutamide + Netupitant-palonosetron
嚴重程度: 嚴重
Apalutamide and Netupitant-palonosetron: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Apalutamide is a strong CYP3A4 inducer and can substantially reduce netupitant exposure, which relies on CYP3A4 for clearance. This may reduce antiemetic efficacy and risk breakthrough nausea and vomiting.
用白話說明這項交互作用的意義
Apalutamide and Netupitant-palonosetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Netupitant-palonosetron belongs to Gastrointestinal Tract.
為什麼會發生
CYP3A4 induction by apalutamide increases netupitant metabolism and lowers its concentrations.
處置方式
Avoid the combination where possible and use an alternative antiemetic regimen. If co-used, monitor for loss of antiemetic control.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Netupitant-palonosetron 的其他交互作用
Apalutamide 的其他交互作用
常見問題
Can I take Apalutamide with Netupitant-palonosetron?
MediHelp rates the interaction as major. Apalutamide and Netupitant-palonosetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a strong CYP3A4 inducer and can substantially reduce netupitant exposure, which relies on CYP3A4 for clearance. This may reduce antiemetic efficacy and risk breakthrough nausea and vomiting.
How serious is the interaction between Apalutamide and Netupitant-palonosetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative antiemetic regimen. If co-used, monitor for loss of antiemetic control.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Avapritinib. The full list is on the Netupitant-palonosetron page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
