藥物交互作用
Enzalutamide + Nirmatrelvir
嚴重程度: 禁忌併用
Enzalutamide and Nirmatrelvir: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Strong CYP3A4 inducers markedly lower nirmatrelvir concentrations, risking loss of antiviral efficacy against SARS-CoV-2 and resistance. Labeling contraindicates the combination with inducers.
用白話說明這項交互作用的意義
Enzalutamide and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Enzalutamide belongs to Endocrine; Nirmatrelvir belongs to Anti Virals.
為什麼會發生
Enzalutamide induces CYP3A4, accelerating nirmatrelvir clearance.
處置方式
Do not use together; consider an alternative COVID-19 therapy such as remdesivir. Induction persists after stopping enzalutamide, so allow a washout before starting nirmatrelvir.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Enzalutamide 的其他交互作用
Nirmatrelvir 的其他交互作用
常見問題
Can I take Enzalutamide with Nirmatrelvir?
MediHelp rates the interaction as contraindicated. Enzalutamide and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Strong CYP3A4 inducers markedly lower nirmatrelvir concentrations, risking loss of antiviral efficacy against SARS-CoV-2 and resistance. Labeling contraindicates the combination with inducers.
How serious is the interaction between Enzalutamide and Nirmatrelvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; consider an alternative COVID-19 therapy such as remdesivir. Induction persists after stopping enzalutamide, so allow a washout before starting nirmatrelvir.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
