藥物交互作用

Amiodarone + Nirmatrelvir

嚴重程度: 禁忌併用

Amiodarone and Nirmatrelvir: contraindicated interaction.

最後更新 13 十月 2026

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Nirmatrelvir is given with ritonavir, a strong CYP3A4 inhibitor. Amiodarone levels may rise sharply, risking QT prolongation, bradycardia and torsades de pointes.

用白話說明這項交互作用的意義

Amiodarone and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amiodarone belongs to Cardiovascular; Nirmatrelvir belongs to Anti Virals.

證據等級: Moderate

為什麼會發生

Ritonavir-boosted nirmatrelvir inhibits CYP3A4, reducing amiodarone clearance.

處置方式

Avoid the combination and choose an alternative COVID-19 therapy. If use cannot be avoided, seek specialist advice and monitor ECG.

可向藥師詢問的問題

Is there an alternative to one of these two medicines for me?
If both are essential, who is monitoring me and how often?
Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Amiodarone 與 Nirmatrelvir 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

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常見問題

Can I take Amiodarone with Nirmatrelvir?

MediHelp rates the interaction as contraindicated. Amiodarone and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nirmatrelvir is given with ritonavir, a strong CYP3A4 inhibitor. Amiodarone levels may rise sharply, risking QT prolongation, bradycardia and torsades de pointes.

How serious is the interaction between Amiodarone and Nirmatrelvir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative COVID-19 therapy. If use cannot be avoided, seek specialist advice and monitor ECG.

What other medicines interact with Amiodarone?

MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.

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摘要