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Apalutamide + Nirmatrelvir

嚴重程度: 禁忌併用

Apalutamide and Nirmatrelvir: contraindicated interaction.

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僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Apalutamide markedly decreases nirmatrelvir concentrations, which may result in treatment failure for COVID-19 and potential resistance. The inducing effect persists after apalutamide is stopped.

用白話說明這項交互作用的意義

Apalutamide and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Apalutamide belongs to Endocrine; Nirmatrelvir belongs to Anti Virals.

證據等級: Moderate

為什麼會發生

Apalutamide induces CYP3A4, increasing the metabolism of nirmatrelvir.

處置方式

Do not use together; consider another COVID-19 antiviral not affected by induction. Avoid starting nirmatrelvir soon after stopping apalutamide.

可向藥師詢問的問題

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Apalutamide 與 Nirmatrelvir 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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常見問題

Can I take Apalutamide with Nirmatrelvir?

MediHelp rates the interaction as contraindicated. Apalutamide and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide markedly decreases nirmatrelvir concentrations, which may result in treatment failure for COVID-19 and potential resistance. The inducing effect persists after apalutamide is stopped.

How serious is the interaction between Apalutamide and Nirmatrelvir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; consider another COVID-19 antiviral not affected by induction. Avoid starting nirmatrelvir soon after stopping apalutamide.

What other medicines interact with Apalutamide?

MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.

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