藥物交互作用
Ethanol + Secnidazole
嚴重程度: 中度
Ethanol and Secnidazole: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Alcohol taken with nitroimidazoles may cause a disulfiram-like reaction with flushing, nausea, vomiting, abdominal pain and headache. Secnidazole labeling advises avoiding alcohol during and shortly after therapy, although the reaction is less well documented than with metronidazole.
用白話說明這項交互作用的意義
Ethanol and Secnidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Proposed inhibition of aldehyde dehydrogenase causing acetaldehyde accumulation; the mechanism is not firmly established for secnidazole.
處置方式
Advise patients to avoid alcohol and ethanol- or propylene glycol-containing products during treatment and for 2 days after the last dose.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
常見問題
Can I take Ethanol with Secnidazole?
MediHelp rates the interaction as moderate. Ethanol and Secnidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alcohol taken with nitroimidazoles may cause a disulfiram-like reaction with flushing, nausea, vomiting, abdominal pain and headache. Secnidazole labeling advises avoiding alcohol during and shortly after therapy, although the reaction is less well documented than with metronidazole.
How serious is the interaction between Ethanol and Secnidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid alcohol and ethanol- or propylene glycol-containing products during treatment and for 2 days after the last dose.
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