藥物交互作用
Ethinyl estradiol-drospirenone + Exemestane
嚴重程度: 嚴重
Ethinyl estradiol-drospirenone and Exemestane: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Exemestane works by lowering estrogen levels in postmenopausal women with hormone-sensitive breast cancer. Giving an estrogen-containing contraceptive at the same time supplies exogenous estrogen and can counteract the intended therapeutic effect. The pairing is also not appropriate in a patient with estrogen-dependent tumor.
用白話說明這項交互作用的意義
Ethinyl estradiol-drospirenone and Exemestane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ethinyl estradiol-drospirenone belongs to Endocrine; Exemestane belongs to Oncology.
為什麼會發生
Pharmacodynamic antagonism: exogenous ethinyl estradiol opposes the estrogen-lowering effect of aromatase inhibition.
處置方式
Avoid concurrent use of estrogen-containing products with exemestane. Use a non-hormonal method if contraception is needed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Ethinyl estradiol-drospirenone 的其他交互作用
- Ethinyl estradiol-drospirenone + Fezolinetant 禁忌併用
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir 禁忌併用
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir 禁忌併用
- Ethinyl estradiol-drospirenone + Tranexamic acid 禁忌併用
- Aminocaproic acid + Ethinyl estradiol-drospirenone 嚴重
- Amobarbital + Ethinyl estradiol-drospirenone 嚴重
Exemestane 的其他交互作用
常見問題
Can I take Ethinyl estradiol-drospirenone with Exemestane?
MediHelp rates the interaction as major. Ethinyl estradiol-drospirenone and Exemestane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Exemestane works by lowering estrogen levels in postmenopausal women with hormone-sensitive breast cancer. Giving an estrogen-containing contraceptive at the same time supplies exogenous estrogen and can counteract the intended therapeutic effect. The pairing is also not appropriate in a patient with estrogen-dependent tumor.
How serious is the interaction between Ethinyl estradiol-drospirenone and Exemestane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of estrogen-containing products with exemestane. Use a non-hormonal method if contraception is needed.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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