藥物交互作用
Fingolimod + Siponimod
嚴重程度: 禁忌併用
Fingolimod and Siponimod: contraindicated interaction.
最後更新
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摘要
Both drugs are S1P receptor modulators that reduce heart rate and lymphocyte counts. Concurrent use gives duplicated pharmacology with additive bradycardia, conduction effects and immunosuppression.
用白話說明這項交互作用的意義
Fingolimod and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fingolimod belongs to Central Nervous System; Siponimod belongs to Central Nervous System.
為什麼會發生
Duplicate S1P receptor modulation with additive negative chronotropic and immunosuppressive effects.
處置方式
Do not use together; allow an adequate washout when switching, with lymphocyte recovery and cardiac monitoring as indicated.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Fingolimod 的其他交互作用
Siponimod 的其他交互作用
常見問題
Can I take Fingolimod with Siponimod?
MediHelp rates the interaction as contraindicated. Fingolimod and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs are S1P receptor modulators that reduce heart rate and lymphocyte counts. Concurrent use gives duplicated pharmacology with additive bradycardia, conduction effects and immunosuppression.
How serious is the interaction between Fingolimod and Siponimod?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; allow an adequate washout when switching, with lymphocyte recovery and cardiac monitoring as indicated.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
