藥物交互作用
Siponimod + Thioridazine
嚴重程度: 禁忌併用
Siponimod and Thioridazine: contraindicated interaction.
最後更新
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摘要
Siponimod can cause bradycardia and atrioventricular conduction delay at initiation, and thioridazine prolongs QTc. Bradycardia increases vulnerability to torsades de pointes. Siponimod labeling advises against use with QT-prolonging drugs. Thioridazine, a CYP2D6 substrate and inhibitor, is not expected to alter siponimod CYP2C9 metabolism meaningfully.
用白話說明這項交互作用的意義
Siponimod and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Siponimod belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
為什麼會發生
Siponimod-induced heart rate slowing combined with thioridazine-induced QT prolongation increases torsades risk.
處置方式
Avoid the combination; use a different antipsychotic. If it cannot be avoided, obtain cardiology advice and ECG monitoring at initiation.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Thioridazine 的其他交互作用
Siponimod 的其他交互作用
常見問題
Can I take Siponimod with Thioridazine?
MediHelp rates the interaction as contraindicated. Siponimod and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Siponimod can cause bradycardia and atrioventricular conduction delay at initiation, and thioridazine prolongs QTc. Bradycardia increases vulnerability to torsades de pointes. Siponimod labeling advises against use with QT-prolonging drugs. Thioridazine, a CYP2D6 substrate and inhibitor, is not expected to alter siponimod CYP2C9 metabolism meaningfully.
How serious is the interaction between Siponimod and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a different antipsychotic. If it cannot be avoided, obtain cardiology advice and ECG monitoring at initiation.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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