藥物交互作用
Folic acid + Phenobarbital
嚴重程度: 中度
Folic acid and Phenobarbital: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Folic acid may modestly reduce phenobarbital concentrations, and long-term phenobarbital use is associated with lower folate status. The combination can affect seizure control, so folate supplementation should be monitored in patients with epilepsy.
用白話說明這項交互作用的意義
Folic acid and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Phenobarbital induces hepatic enzymes and impairs folate status, while folate may increase anticonvulsant metabolism.
處置方式
Monitor seizure frequency and phenobarbital levels when starting or adjusting folic acid. Supplement folate where indicated at the lowest effective dose.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Folic acid 的其他交互作用
常見問題
Can I take Folic acid with Phenobarbital?
MediHelp rates the interaction as moderate. Folic acid and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Folic acid may modestly reduce phenobarbital concentrations, and long-term phenobarbital use is associated with lower folate status. The combination can affect seizure control, so folate supplementation should be monitored in patients with epilepsy.
How serious is the interaction between Folic acid and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and phenobarbital levels when starting or adjusting folic acid. Supplement folate where indicated at the lowest effective dose.
What other medicines interact with Folic acid?
MediHelp also lists interactions of Folic acid with, for example, Ethotoin, Fosphenytoin, Glucarpidase. The full list is on the Folic acid page.
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