藥物交互作用
Folic acid + Phenytoin
嚴重程度: 中度
Folic acid and Phenytoin: moderate interaction.
最後更新
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摘要
Folic acid, especially at high doses, can lower serum phenytoin levels and has been linked with reduced seizure control. Phenytoin can also lower folate levels, so supplementation is often needed.
用白話說明這項交互作用的意義
Folic acid and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Folic acid belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
為什麼會發生
Folate may increase the hepatic metabolism of phenytoin, while phenytoin impairs folate absorption and status.
處置方式
Monitor phenytoin levels and seizure frequency when starting or adjusting folic acid. Adjust the phenytoin dose if levels fall.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Phenytoin 的其他交互作用
Folic acid 的其他交互作用
常見問題
Can I take Folic acid with Phenytoin?
MediHelp rates the interaction as moderate. Folic acid and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Folic acid, especially at high doses, can lower serum phenytoin levels and has been linked with reduced seizure control. Phenytoin can also lower folate levels, so supplementation is often needed.
How serious is the interaction between Folic acid and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin levels and seizure frequency when starting or adjusting folic acid. Adjust the phenytoin dose if levels fall.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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