藥物交互作用
Fostemsavir + Phenytoin
嚴重程度: 禁忌併用
Fostemsavir and Phenytoin: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Phenytoin substantially lowers temsavir, the active moiety of fostemsavir, risking loss of virologic response and resistance.
用白話說明這項交互作用的意義
Fostemsavir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fostemsavir belongs to Anti Virals; Phenytoin belongs to Central Nervous System.
為什麼會發生
Phenytoin induces CYP3A4, which metabolizes temsavir.
處置方式
Do not co-administer; use a non-inducing antiepileptic such as levetiracetam.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Phenytoin 的其他交互作用
Fostemsavir 的其他交互作用
常見問題
Can I take Fostemsavir with Phenytoin?
MediHelp rates the interaction as contraindicated. Fostemsavir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin substantially lowers temsavir, the active moiety of fostemsavir, risking loss of virologic response and resistance.
How serious is the interaction between Fostemsavir and Phenytoin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-inducing antiepileptic such as levetiracetam.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
