藥品參考
Fostemsavir
Fostemsavir is a medicine in the class anti virals. It is used for hiv.
- 藥物類別: Anti Virals
- 用途: hiv
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Anti Virals
- 常見劑型
- 錠劑
- 常見規格
- 600 mg
- 已知交互作用
- 157 (禁忌併用: 6 · 嚴重: 5 · 中度: 114 · 輕微: 32)
- 商品名
- 2
- 國家與市場
- 2
用途
作用方式
HIV-1 gp120-directed attachment inhibitor; HIV-1 antiretroviral agent. Fostemsavir is a prodrug of temsavir, the active moiety.
成人常用劑量（仿單摘要）
HIV-1 infection in heavily treatment-experienced adults with multidrug-resistant HIV-1 (with other antiretrovirals): 600 mg tablet orally twice daily with or without food
懷孕與哺乳
- 懷孕
- Unknown Insufficient human data to assess risk; no adverse developmental effects in rats and rabbits at clinically relevant exposures. Pregnancy registry exists. Used in heavily treated HIV when other options fail; continue if needed for viral control.
- 哺乳
- Unknown Not known whether it is in human milk; it is in rat milk. Risks include HIV transmission, viral resistance and infant side effects. US guidance supports breastfeeding only with sustained viral suppression after counselling; otherwise avoid.
已通報的副作用
- Nausea
- Diarrhea
- Headache
- Abdominal pain
- Dyspepsia
- Fatigue
禁忌症
- Previous hypersensitivity to fostemsavir or any component of the formulation.
- Coadministration with strong CYP3A inducers (e.g., enzalutamide, carbamazepine, phenytoin, rifampin, mitotane, St John's wort) because of loss of virologic response.
哪些人需要特別留意
- Immune reconstitution syndrome, including inflammatory responses to opportunistic infections and autoimmune disorders, has been reported.
- QTc prolongation seen at higher than recommended doses; use caution with history of QT prolongation, cardiac disease, or drugs with Torsade de Pointes risk.
- Hepatic transaminase elevations in HBV/HCV co-infection, including hepatitis B reactivation; monitor liver chemistries.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (157)
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Efavirenz + Fostemsavir Major
- Fostemsavir + Lorlatinib Major
- Fostemsavir + Pimozide Major
- Fostemsavir + Sofosbuvir-velpatasvir-voxilaprevir Major
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Fostemsavir 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
在網頁版免費試用 Pro+ 14 天，無需信用卡。
同類別的其他藥品
常見問題
What is Fostemsavir used for?
Fostemsavir is a medicine in the class anti virals. It is used for HIV.
What side effects have been reported with Fostemsavir?
Nausea, Diarrhea, Headache, Abdominal pain, Dyspepsia, Fatigue.
Can Fostemsavir be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Insufficient human data to assess risk; no adverse developmental effects in rats and rabbits at clinically relevant exposures. Pregnancy registry exists. Used in heavily treated HIV when other options fail; continue if needed for viral control. Breastfeeding: Unknown. Not known whether it is in human milk; it is in rat milk. Risks include HIV transmission, viral resistance and infant side effects. US guidance supports breastfeeding only with sustained viral suppression after counselling; otherwise avoid.
What does Fostemsavir interact with?
MediHelp lists 157 known interactions for Fostemsavir. Contraindicated: 6 · Major: 5 · Moderate: 114 · Minor: 32. The most serious include Apalutamide, Carbamazepine, Enzalutamide.
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