藥物交互作用

Fostemsavir + Mitotane

嚴重程度: 禁忌併用

Fostemsavir and Mitotane: contraindicated interaction.

最後更新 14 十月 2026

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Mitotane is a strong, long-acting CYP3A4 inducer and is expected to lower temsavir concentrations. Induction persists for weeks after stopping mitotane.

用白話說明這項交互作用的意義

Fostemsavir and Mitotane are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Fostemsavir belongs to Anti Virals; Mitotane belongs to Oncology.

證據等級: Moderate

為什麼會發生

Mitotane induces CYP3A4, increasing temsavir metabolism.

處置方式

Avoid the combination, including shortly after mitotane discontinuation; choose an alternative antiretroviral.

可向藥師詢問的問題

Is there an alternative to one of these two medicines for me?
If both are essential, who is monitoring me and how often?
Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Fostemsavir 與 Mitotane 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

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常見問題

Can I take Fostemsavir with Mitotane?

MediHelp rates the interaction as contraindicated. Fostemsavir and Mitotane are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mitotane is a strong, long-acting CYP3A4 inducer and is expected to lower temsavir concentrations. Induction persists for weeks after stopping mitotane.

How serious is the interaction between Fostemsavir and Mitotane?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, including shortly after mitotane discontinuation; choose an alternative antiretroviral.

What other medicines interact with Fostemsavir?

MediHelp also lists interactions of Fostemsavir with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Fostemsavir page.

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摘要