藥物交互作用
Gemifloxacin + Thioridazine
嚴重程度: 禁忌併用
Gemifloxacin and Thioridazine: contraindicated interaction.
最後更新
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摘要
Gemifloxacin is a fluoroquinolone that can modestly prolong the QTc, and thioridazine has one of the strongest QTc effects among the antipsychotics. Using them together adds to delayed repolarisation and raises the risk of torsades de pointes, especially with hypokalaemia, hypomagnesaemia, bradycardia or structural heart disease.
用白話說明這項交互作用的意義
Gemifloxacin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Gemifloxacin belongs to Anti Bacterial; Thioridazine belongs to Central Nervous System.
為什麼會發生
Additive blockade of cardiac repolarising potassium currents (hERG)
處置方式
Do not co-prescribe; choose an agent without QT liability. If one drug cannot be stopped, correct electrolytes and monitor the ECG closely.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Gemifloxacin 的其他交互作用
Thioridazine 的其他交互作用
常見問題
Can I take Gemifloxacin with Thioridazine?
MediHelp rates the interaction as contraindicated. Gemifloxacin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gemifloxacin is a fluoroquinolone that can modestly prolong the QTc, and thioridazine has one of the strongest QTc effects among the antipsychotics. Using them together adds to delayed repolarisation and raises the risk of torsades de pointes, especially with hypokalaemia, hypomagnesaemia, bradycardia or structural heart disease.
How serious is the interaction between Gemifloxacin and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe; choose an agent without QT liability. If one drug cannot be stopped, correct electrolytes and monitor the ECG closely.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
