藥物交互作用
Heparin + Oritavancin
嚴重程度: 禁忌併用
Heparin and Oritavancin: contraindicated interaction.
最後更新
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摘要
Oritavancin artificially prolongs aPTT for many days, so unfractionated heparin monitoring becomes unreliable. This may lead to inappropriate dosing and bleeding or thrombosis.
用白話說明這項交互作用的意義
Heparin and Oritavancin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Heparin belongs to Cardiovascular; Oritavancin belongs to Anti Bacterial.
為什麼會發生
Oritavancin binds phospholipid reagents used in coagulation assays, causing laboratory interference rather than a true pharmacodynamic effect.
處置方式
Avoid IV unfractionated heparin for the period stated in labeling after oritavancin. Use an alternative anticoagulant monitored by a non-aPTT method if needed.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Oritavancin 的其他交互作用
Heparin 的其他交互作用
常見問題
Can I take Heparin with Oritavancin?
MediHelp rates the interaction as contraindicated. Heparin and Oritavancin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oritavancin artificially prolongs aPTT for many days, so unfractionated heparin monitoring becomes unreliable. This may lead to inappropriate dosing and bleeding or thrombosis.
How serious is the interaction between Heparin and Oritavancin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid IV unfractionated heparin for the period stated in labeling after oritavancin. Use an alternative anticoagulant monitored by a non-aPTT method if needed.
What other medicines interact with Oritavancin?
MediHelp also lists interactions of Oritavancin with, for example, Warfarin, Carbamazepine, Cyclosporin. The full list is on the Oritavancin page.
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