藥物交互作用
Oritavancin + Warfarin
嚴重程度: 中度
Oritavancin and Warfarin: moderate interaction.
最後更新
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摘要
Oritavancin artificially prolongs PT/INR and aPTT in laboratory tests for hours to days after dosing, so coagulation results may not reflect true anticoagulation in warfarin-treated patients. Oritavancin may also modestly raise warfarin exposure, so true bleeding risk may be increased.
用白話說明這項交互作用的意義
Oritavancin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oritavancin belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
為什麼會發生
Oritavancin binds and interferes with phospholipid reagents used in clotting assays, and may weakly inhibit CYP2C9 and so reduce warfarin clearance.
處置方式
Avoid relying on INR measurements shortly after oritavancin dosing and monitor the patient clinically for bleeding. Consider alternative anticoagulation monitoring or a different antibiotic if tight INR control is needed.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Oritavancin 的其他交互作用
Warfarin 的其他交互作用
常見問題
Can I take Oritavancin with Warfarin?
MediHelp rates the interaction as moderate. Oritavancin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oritavancin artificially prolongs PT/INR and aPTT in laboratory tests for hours to days after dosing, so coagulation results may not reflect true anticoagulation in warfarin-treated patients. Oritavancin may also modestly raise warfarin exposure, so true bleeding risk may be increased.
How serious is the interaction between Oritavancin and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid relying on INR measurements shortly after oritavancin dosing and monitor the patient clinically for bleeding. Consider alternative anticoagulation monitoring or a different antibiotic if tight INR control is needed.
What other medicines interact with Oritavancin?
MediHelp also lists interactions of Oritavancin with, for example, Heparin, Carbamazepine, Cyclosporin. The full list is on the Oritavancin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
