藥物交互作用
Hydrocodone + Phenelzine
嚴重程度: 禁忌併用
Hydrocodone and Phenelzine: contraindicated interaction.
最後更新
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摘要
MAOIs combined with opioids can cause serotonin syndrome or severe opioid toxicity including respiratory depression and coma. Labeling advises against opioid use during and for 14 days after MAOI therapy.
用白話說明這項交互作用的意義
Hydrocodone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydrocodone belongs to Musculoskeletal; Phenelzine belongs to Central Nervous System.
為什麼會發生
Inhibition of monoamine oxidase raises serotonergic and noradrenergic activity, with possible potentiation of opioid CNS effects.
處置方式
Avoid hydrocodone during MAOI therapy and for 14 days after stopping. Choose a non-serotonergic analgesic strategy and monitor closely if an opioid is unavoidable.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Hydrocodone 的其他交互作用
Phenelzine 的其他交互作用
常見問題
Can I take Hydrocodone with Phenelzine?
MediHelp rates the interaction as contraindicated. Hydrocodone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAOIs combined with opioids can cause serotonin syndrome or severe opioid toxicity including respiratory depression and coma. Labeling advises against opioid use during and for 14 days after MAOI therapy.
How serious is the interaction between Hydrocodone and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid hydrocodone during MAOI therapy and for 14 days after stopping. Choose a non-serotonergic analgesic strategy and monitor closely if an opioid is unavoidable.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
