藥物交互作用
Hydrocodone + Isocarboxazid
嚴重程度: 禁忌併用
Hydrocodone and Isocarboxazid: contraindicated interaction.
最後更新
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摘要
MAO inhibitors given with opioids can cause serotonin syndrome or unpredictable opioid toxicity, including respiratory depression and coma. The risk persists for about two weeks after the MAOI is stopped.
用白話說明這項交互作用的意義
Hydrocodone and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydrocodone belongs to Musculoskeletal; Isocarboxazid belongs to Central Nervous System.
為什麼會發生
Nonselective MAO inhibition raises serotonergic and noradrenergic activity and may alter opioid effects, causing serotonin toxicity or CNS depression.
處置方式
Do not use hydrocodone during or within 14 days of an MAOI; choose a non-opioid or non-interacting analgesic. If an opioid is unavoidable, use closely monitored small test doses.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Hydrocodone 的其他交互作用
Isocarboxazid 的其他交互作用
常見問題
Can I take Hydrocodone with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Hydrocodone and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAO inhibitors given with opioids can cause serotonin syndrome or unpredictable opioid toxicity, including respiratory depression and coma. The risk persists for about two weeks after the MAOI is stopped.
How serious is the interaction between Hydrocodone and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use hydrocodone during or within 14 days of an MAOI; choose a non-opioid or non-interacting analgesic. If an opioid is unavoidable, use closely monitored small test doses.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Olanzapine / samidorphan. The full list is on the Hydrocodone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
