藥物交互作用
Hydromorphone + Olanzapine / samidorphan
嚴重程度: 禁忌併用
Hydromorphone and Olanzapine / samidorphan: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Samidorphan is an opioid antagonist that blocks hydromorphone's effect and can precipitate acute withdrawal in opioid-dependent patients. Pain control may be lost.
用白話說明這項交互作用的意義
Hydromorphone and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Pharmacodynamic antagonism at opioid receptors by samidorphan.
處置方式
Do not start in patients using opioids; ensure an opioid-free interval of at least 7 days for short-acting opioids before starting. Choose another antipsychotic if opioid therapy is needed.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Hydromorphone 的其他交互作用
常見問題
Can I take Hydromorphone with Olanzapine / samidorphan?
MediHelp rates the interaction as contraindicated. Hydromorphone and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan is an opioid antagonist that blocks hydromorphone's effect and can precipitate acute withdrawal in opioid-dependent patients. Pain control may be lost.
How serious is the interaction between Hydromorphone and Olanzapine / samidorphan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not start in patients using opioids; ensure an opioid-free interval of at least 7 days for short-acting opioids before starting. Choose another antipsychotic if opioid therapy is needed.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
