藥物交互作用
Bupropion-naltrexone + Hydromorphone
嚴重程度: 禁忌併用
Bupropion-naltrexone and Hydromorphone: contraindicated interaction.
最後更新
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摘要
Naltrexone blocks opioid receptors, so it antagonizes hydromorphone analgesia and can precipitate withdrawal in opioid-dependent patients. Hydromorphone is not primarily CYP2D6 dependent, so the pharmacokinetic effect of bupropion is minor by comparison.
用白話說明這項交互作用的意義
Bupropion-naltrexone and Hydromorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion-naltrexone belongs to Miscellaneous; Hydromorphone belongs to Musculoskeletal.
為什麼會發生
Naltrexone competitively antagonizes mu opioid receptors, opposing hydromorphone effects.
處置方式
Avoid concurrent use; the product is contraindicated with chronic opioid therapy. Allow an adequate opioid-free interval before starting.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Bupropion-naltrexone 的其他交互作用
Hydromorphone 的其他交互作用
常見問題
Can I take Bupropion-naltrexone with Hydromorphone?
MediHelp rates the interaction as contraindicated. Bupropion-naltrexone and Hydromorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Naltrexone blocks opioid receptors, so it antagonizes hydromorphone analgesia and can precipitate withdrawal in opioid-dependent patients. Hydromorphone is not primarily CYP2D6 dependent, so the pharmacokinetic effect of bupropion is minor by comparison.
How serious is the interaction between Bupropion-naltrexone and Hydromorphone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; the product is contraindicated with chronic opioid therapy. Allow an adequate opioid-free interval before starting.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Isocarboxazid, Linezolid. The full list is on the Bupropion-naltrexone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
