藥物交互作用
Hydromorphone + Phenelzine
嚴重程度: 禁忌併用
Hydromorphone and Phenelzine: contraindicated interaction.
最後更新
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摘要
Opioids given with nonselective MAOIs have caused severe reactions including hypotension, hyperthermia, respiratory depression and coma. Hydromorphone labeling advises against use during or within 14 days of MAOI therapy.
用白話說明這項交互作用的意義
Hydromorphone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydromorphone belongs to Musculoskeletal; Phenelzine belongs to Central Nervous System.
為什麼會發生
Irreversible MAO inhibition may potentiate opioid CNS and respiratory depression and cause serotonergic or autonomic instability; the exact mechanism is not fully defined.
處置方式
Avoid concurrent use and wait at least 14 days after stopping phenelzine before giving hydromorphone. Select an alternative analgesic if the patient is on an MAOI.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Hydromorphone 的其他交互作用
Phenelzine 的其他交互作用
常見問題
Can I take Hydromorphone with Phenelzine?
MediHelp rates the interaction as contraindicated. Hydromorphone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids given with nonselective MAOIs have caused severe reactions including hypotension, hyperthermia, respiratory depression and coma. Hydromorphone labeling advises against use during or within 14 days of MAOI therapy.
How serious is the interaction between Hydromorphone and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and wait at least 14 days after stopping phenelzine before giving hydromorphone. Select an alternative analgesic if the patient is on an MAOI.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
