藥物交互作用
Hydroxyurea + Interferon beta 1a
嚴重程度: 嚴重
Hydroxyurea and Interferon beta 1a: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Cutaneous vasculitic toxicities, including ulceration and gangrene, have been reported in patients receiving hydroxyurea who have current or prior interferon exposure. The events can be severe and may require stopping therapy.
用白話說明這項交互作用的意義
Hydroxyurea and Interferon beta 1a can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxyurea belongs to Miscellaneous; Interferon beta 1a belongs to Central Nervous System.
為什麼會發生
The mechanism is not well established; additive vascular and cutaneous toxicity is suspected.
處置方式
Examine the skin regularly for ulceration or vasculitic lesions and discontinue hydroxyurea if they develop; consider alternatives in patients with prior interferon exposure.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Interferon beta 1a 的其他交互作用
Hydroxyurea 的其他交互作用
常見問題
Can I take Hydroxyurea with Interferon beta 1a?
MediHelp rates the interaction as major. Hydroxyurea and Interferon beta 1a can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cutaneous vasculitic toxicities, including ulceration and gangrene, have been reported in patients receiving hydroxyurea who have current or prior interferon exposure. The events can be severe and may require stopping therapy.
How serious is the interaction between Hydroxyurea and Interferon beta 1a?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Examine the skin regularly for ulceration or vasculitic lesions and discontinue hydroxyurea if they develop; consider alternatives in patients with prior interferon exposure.
What other medicines interact with Interferon beta 1a?
MediHelp also lists interactions of Interferon beta 1a with, for example, Deferiprone, Etrasimod, Idecabtagene vicleucel. The full list is on the Interferon beta 1a page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
