藥物交互作用
Didanosine + Hydroxyurea
嚴重程度: 禁忌併用
Didanosine and Hydroxyurea: contraindicated interaction.
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摘要
Hydroxyurea combined with didanosine has caused pancreatitis, hepatotoxicity including fatal hepatic failure, and peripheral neuropathy in HIV patients. The overlapping toxicities make the combination dangerous.
用白話說明這項交互作用的意義
Didanosine and Hydroxyurea are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Didanosine belongs to Anti Virals; Hydroxyurea belongs to Miscellaneous.
為什麼會發生
Additive pancreatic, hepatic and neurotoxicity; the exact mechanism is not fully established.
處置方式
Do not combine; choose a different antiretroviral. If exposure has occurred, monitor for pancreatitis, liver injury and neuropathy and stop the agents if signs appear.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Didanosine 的其他交互作用
Hydroxyurea 的其他交互作用
常見問題
Can I take Didanosine with Hydroxyurea?
MediHelp rates the interaction as contraindicated. Didanosine and Hydroxyurea are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydroxyurea combined with didanosine has caused pancreatitis, hepatotoxicity including fatal hepatic failure, and peripheral neuropathy in HIV patients. The overlapping toxicities make the combination dangerous.
How serious is the interaction between Didanosine and Hydroxyurea?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose a different antiretroviral. If exposure has occurred, monitor for pancreatitis, liver injury and neuropathy and stop the agents if signs appear.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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