藥物交互作用
Indinavir + Midazolam
嚴重程度: 禁忌併用
Indinavir and Midazolam: contraindicated interaction.
最後更新
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摘要
Indinavir inhibits CYP3A4 and can increase midazolam exposure, leading to excessive and prolonged sedation and respiratory depression.
用白話說明這項交互作用的意義
Indinavir and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Indinavir inhibits CYP3A4 metabolism of midazolam.
處置方式
Avoid oral midazolam. If parenteral dosing is needed, reduce the dose and monitor sedation and respiration.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Midazolam 的其他交互作用
常見問題
Can I take Indinavir with Midazolam?
MediHelp rates the interaction as contraindicated. Indinavir and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Indinavir inhibits CYP3A4 and can increase midazolam exposure, leading to excessive and prolonged sedation and respiratory depression.
How serious is the interaction between Indinavir and Midazolam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral midazolam. If parenteral dosing is needed, reduce the dose and monitor sedation and respiration.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
