藥物交互作用
Cobicistat + Midazolam
嚴重程度: 禁忌併用
Cobicistat and Midazolam: contraindicated interaction.
最後更新
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摘要
Cobicistat strongly inhibits CYP3A and can greatly increase midazolam exposure, particularly after oral dosing. Prolonged sedation and respiratory depression can occur and are potentially life-threatening.
用白話說明這項交互作用的意義
Cobicistat and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Midazolam belongs to Central Nervous System.
為什麼會發生
Cobicistat inhibits intestinal and hepatic CYP3A4, blocking midazolam first-pass and systemic metabolism.
處置方式
Avoid oral midazolam. If single-dose parenteral midazolam is needed, use a reduced dose in a monitored setting with respiratory support available.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Midazolam 的其他交互作用
Cobicistat 的其他交互作用
常見問題
Can I take Cobicistat with Midazolam?
MediHelp rates the interaction as contraindicated. Cobicistat and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat strongly inhibits CYP3A and can greatly increase midazolam exposure, particularly after oral dosing. Prolonged sedation and respiratory depression can occur and are potentially life-threatening.
How serious is the interaction between Cobicistat and Midazolam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral midazolam. If single-dose parenteral midazolam is needed, use a reduced dose in a monitored setting with respiratory support available.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Midazolam page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
