藥物交互作用
Indomethacin + Ketorolac
嚴重程度: 禁忌併用
Indomethacin and Ketorolac: contraindicated interaction.
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摘要
Ketorolac labelling prohibits its use with other NSAIDs, including indomethacin. Two NSAIDs together add to gastrointestinal ulceration and bleeding, renal impairment and platelet inhibition without extra analgesic benefit.
用白話說明這項交互作用的意義
Indomethacin and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Indomethacin belongs to Musculoskeletal; Ketorolac belongs to Musculoskeletal.
為什麼會發生
Additive COX inhibition (gastrointestinal, renal and antiplatelet toxicity)
處置方式
Do not combine; use ketorolac alone for its short course (5 days maximum) or indomethacin alone, not both.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Indomethacin 的其他交互作用
Ketorolac 的其他交互作用
常見問題
Can I take Indomethacin with Ketorolac?
MediHelp rates the interaction as contraindicated. Indomethacin and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac labelling prohibits its use with other NSAIDs, including indomethacin. Two NSAIDs together add to gastrointestinal ulceration and bleeding, renal impairment and platelet inhibition without extra analgesic benefit.
How serious is the interaction between Indomethacin and Ketorolac?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use ketorolac alone for its short course (5 days maximum) or indomethacin alone, not both.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac intranasal, Aceclofenac, Acemetacin. The full list is on the Indomethacin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
