藥物交互作用
Insulin degludec + Pioglitazone
嚴重程度: 嚴重
Insulin degludec and Pioglitazone: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Pioglitazone increases insulin sensitivity and enhances the glucose-lowering effect of insulin, which increases hypoglycemia risk. Both drugs can also cause fluid retention, so the combination raises the risk of edema and heart failure.
用白話說明這項交互作用的意義
Insulin degludec and Pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec belongs to Endocrine; Pioglitazone belongs to Endocrine.
為什麼會發生
Additive glucose lowering from improved insulin sensitivity plus exogenous insulin; thiazolidinedione-related fluid retention is also additive with insulin.
處置方式
Monitor blood glucose and reduce the insulin dose if hypoglycemia occurs. Monitor for weight gain, edema and heart failure symptoms, and avoid in patients with symptomatic heart failure.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Insulin degludec 的其他交互作用
Pioglitazone 的其他交互作用
常見問題
Can I take Insulin degludec with Pioglitazone?
MediHelp rates the interaction as major. Insulin degludec and Pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pioglitazone increases insulin sensitivity and enhances the glucose-lowering effect of insulin, which increases hypoglycemia risk. Both drugs can also cause fluid retention, so the combination raises the risk of edema and heart failure.
How serious is the interaction between Insulin degludec and Pioglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the insulin dose if hypoglycemia occurs. Monitor for weight gain, edema and heart failure symptoms, and avoid in patients with symptomatic heart failure.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
