藥物交互作用
Insulin detemir + Pioglitazone
嚴重程度: 嚴重
Insulin detemir and Pioglitazone: major interaction.
最後更新
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摘要
Pioglitazone with insulin increases the risk of fluid retention, edema and heart failure and adds to glucose lowering with a risk of hypoglycemia.
用白話說明這項交互作用的意義
Insulin detemir and Pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin detemir belongs to Endocrine; Pioglitazone belongs to Endocrine.
為什麼會發生
Thiazolidinedione-induced sodium and fluid retention is additive with insulin's antinatriuretic effect, and both lower glucose through additive pharmacodynamic action.
處置方式
Monitor for weight gain, edema and heart failure symptoms, and avoid in patients with significant cardiac disease. Reduce the insulin dose if hypoglycemia occurs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Insulin detemir 的其他交互作用
Pioglitazone 的其他交互作用
常見問題
Can I take Insulin detemir with Pioglitazone?
MediHelp rates the interaction as major. Insulin detemir and Pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pioglitazone with insulin increases the risk of fluid retention, edema and heart failure and adds to glucose lowering with a risk of hypoglycemia.
How serious is the interaction between Insulin detemir and Pioglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for weight gain, edema and heart failure symptoms, and avoid in patients with significant cardiac disease. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
