藥物交互作用
Insulin lispro + Pioglitazone
嚴重程度: 嚴重
Insulin lispro and Pioglitazone: major interaction.
最後更新
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摘要
Pioglitazone improves insulin sensitivity and adds to insulin's glucose lowering, increasing hypoglycemia risk. Both agents promote fluid retention, so the combination raises the risk of edema and heart failure.
用白話說明這項交互作用的意義
Insulin lispro and Pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin lispro belongs to Endocrine; Pioglitazone belongs to Endocrine.
為什麼會發生
Additive glucose lowering through insulin sensitization plus insulin, with PPAR-gamma-mediated renal sodium and fluid retention potentiated by insulin.
處置方式
Monitor for weight gain, edema and heart failure symptoms, and reduce the insulin dose if hypoglycemia occurs. Avoid in patients with symptomatic heart failure.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Insulin lispro 的其他交互作用
Pioglitazone 的其他交互作用
常見問題
Can I take Insulin lispro with Pioglitazone?
MediHelp rates the interaction as major. Insulin lispro and Pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pioglitazone improves insulin sensitivity and adds to insulin's glucose lowering, increasing hypoglycemia risk. Both agents promote fluid retention, so the combination raises the risk of edema and heart failure.
How serious is the interaction between Insulin lispro and Pioglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for weight gain, edema and heart failure symptoms, and reduce the insulin dose if hypoglycemia occurs. Avoid in patients with symptomatic heart failure.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
