藥物交互作用
Ketoconazole + Pralsetinib
嚴重程度: 嚴重
Ketoconazole and Pralsetinib: major interaction.
最後更新
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摘要
Ketoconazole increases pralsetinib exposure and may intensify adverse effects such as hepatotoxicity, hypertension, hemorrhage, pneumonitis and myelosuppression.
用白話說明這項交互作用的意義
Ketoconazole and Pralsetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoconazole belongs to Anti Fungals; Pralsetinib belongs to Oncology.
為什麼會發生
Combined inhibition of CYP3A4 metabolism and P-glycoprotein efflux of pralsetinib.
處置方式
Avoid the combination if possible; if required, reduce the pralsetinib dose per labeling and restore it after 3 to 5 half-lives of the inhibitor have elapsed post-discontinuation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Ketoconazole 的其他交互作用
Pralsetinib 的其他交互作用
常見問題
Can I take Ketoconazole with Pralsetinib?
MediHelp rates the interaction as major. Ketoconazole and Pralsetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoconazole increases pralsetinib exposure and may intensify adverse effects such as hepatotoxicity, hypertension, hemorrhage, pneumonitis and myelosuppression.
How serious is the interaction between Ketoconazole and Pralsetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if required, reduce the pralsetinib dose per labeling and restore it after 3 to 5 half-lives of the inhibitor have elapsed post-discontinuation.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
