藥物交互作用
Ketoconazole + Voclosporin
嚴重程度: 禁忌併用
Ketoconazole and Voclosporin: contraindicated interaction.
最後更新
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摘要
Ketoconazole substantially increases voclosporin exposure, raising the risk of nephrotoxicity, hypertension and other calcineurin inhibitor toxicity. Labeling contraindicates strong CYP3A4 inhibitors.
用白話說明這項交互作用的意義
Ketoconazole and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ketoconazole belongs to Anti Fungals; Voclosporin belongs to Miscellaneous.
為什麼會發生
Strong CYP3A4 inhibition decreases voclosporin clearance.
處置方式
Avoid. Choose an antifungal without strong CYP3A4 inhibition and monitor renal function.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ketoconazole 的其他交互作用
Voclosporin 的其他交互作用
常見問題
Can I take Ketoconazole with Voclosporin?
MediHelp rates the interaction as contraindicated. Ketoconazole and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole substantially increases voclosporin exposure, raising the risk of nephrotoxicity, hypertension and other calcineurin inhibitor toxicity. Labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Ketoconazole and Voclosporin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid. Choose an antifungal without strong CYP3A4 inhibition and monitor renal function.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
