藥物交互作用
Clarithromycin + Voclosporin
嚴重程度: 禁忌併用
Clarithromycin and Voclosporin: contraindicated interaction.
最後更新
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摘要
Clarithromycin markedly increases voclosporin concentrations. This raises the risk of nephrotoxicity, hypertension, neurotoxicity, QT prolongation and over-immunosuppression. Voclosporin labeling contraindicates strong CYP3A4 inhibitors.
用白話說明這項交互作用的意義
Clarithromycin and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
為什麼會發生
Strong CYP3A4 inhibition (and P-glycoprotein inhibition) decreases voclosporin clearance.
處置方式
Avoid the combination and use a non-inhibiting antibiotic such as azithromycin if suitable. If a macrolide course cannot be avoided, hold voclosporin per specialist guidance and monitor renal function and blood pressure.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Clarithromycin 的其他交互作用
Voclosporin 的其他交互作用
常見問題
Can I take Clarithromycin with Voclosporin?
MediHelp rates the interaction as contraindicated. Clarithromycin and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin markedly increases voclosporin concentrations. This raises the risk of nephrotoxicity, hypertension, neurotoxicity, QT prolongation and over-immunosuppression. Voclosporin labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Clarithromycin and Voclosporin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inhibiting antibiotic such as azithromycin if suitable. If a macrolide course cannot be avoided, hold voclosporin per specialist guidance and monitor renal function and blood pressure.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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