藥物交互作用
Lamivudine + Sorbitol
嚴重程度: 中度
Lamivudine and Sorbitol: moderate interaction.
最後更新
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摘要
Sorbitol-containing liquid medicines taken with lamivudine oral solution lower lamivudine exposure in a dose-related way. Reduced exposure may lead to inadequate viral suppression and resistance, especially in children.
用白話說明這項交互作用的意義
Lamivudine and Sorbitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lamivudine belongs to Anti Virals; Sorbitol belongs to Gastrointestinal Tract.
為什麼會發生
Sorbitol appears to reduce lamivudine absorption, possibly through osmotic effects on the gut; the mechanism is not fully established.
處置方式
Avoid regular co-administration of sorbitol-containing solutions with lamivudine where possible. If unavoidable, monitor viral load closely or use lamivudine tablets or a sorbitol-free formulation.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Lamivudine 的其他交互作用
Sorbitol 的其他交互作用
常見問題
Can I take Lamivudine with Sorbitol?
MediHelp rates the interaction as moderate. Lamivudine and Sorbitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorbitol-containing liquid medicines taken with lamivudine oral solution lower lamivudine exposure in a dose-related way. Reduced exposure may lead to inadequate viral suppression and resistance, especially in children.
How serious is the interaction between Lamivudine and Sorbitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular co-administration of sorbitol-containing solutions with lamivudine where possible. If unavoidable, monitor viral load closely or use lamivudine tablets or a sorbitol-free formulation.
What other medicines interact with Lamivudine?
MediHelp also lists interactions of Lamivudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Atidarsagene autotemcel, Betibeglogene autotemcel. The full list is on the Lamivudine page.
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