藥物交互作用
Atidarsagene autotemcel + Lamivudine
嚴重程度: 嚴重
Atidarsagene autotemcel and Lamivudine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Antiretrovirals such as lamivudine can interfere with manufacture of the gene-modified cell product because they inhibit the lentiviral vector transduction process. Patients taking them around the time of cell collection may produce an inadequate or unusable product.
用白話說明這項交互作用的意義
Atidarsagene autotemcel and Lamivudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Lamivudine belongs to Anti Virals.
為什麼會發生
Nucleoside reverse transcriptase inhibitors block reverse transcription of the lentiviral vector, impairing transduction of harvested cells.
處置方式
Stop lamivudine at least one month before cell mobilization, or longer for drug elimination, and keep it off until apheresis is complete. Consult an HIV specialist for an alternative plan.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Lamivudine 的其他交互作用
Atidarsagene autotemcel 的其他交互作用
常見問題
Can I take Atidarsagene autotemcel with Lamivudine?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Lamivudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretrovirals such as lamivudine can interfere with manufacture of the gene-modified cell product because they inhibit the lentiviral vector transduction process. Patients taking them around the time of cell collection may produce an inadequate or unusable product.
How serious is the interaction between Atidarsagene autotemcel and Lamivudine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop lamivudine at least one month before cell mobilization, or longer for drug elimination, and keep it off until apheresis is complete. Consult an HIV specialist for an alternative plan.
What other medicines interact with Lamivudine?
MediHelp also lists interactions of Lamivudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Betibeglogene autotemcel, Elivaldogene autotemcel. The full list is on the Lamivudine page.
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