藥物交互作用
Ledipasvir-sofosbuvir + Phenytoin
嚴重程度: 禁忌併用
Ledipasvir-sofosbuvir and Phenytoin: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Phenytoin is an inducer of P-gp and CYP enzymes and is expected to substantially reduce ledipasvir and sofosbuvir exposure. This can cause failure of hepatitis C therapy. Labeling advises against use together.
用白話說明這項交互作用的意義
Ledipasvir-sofosbuvir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ledipasvir-sofosbuvir belongs to Anti Virals; Phenytoin belongs to Central Nervous System.
為什麼會發生
Phenytoin induces P-glycoprotein and metabolic enzymes, reducing absorption and exposure of sofosbuvir and ledipasvir.
處置方式
Do not coadminister; replace phenytoin with a non-inducing antiepileptic before and during HCV treatment.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ledipasvir-sofosbuvir 的其他交互作用
Phenytoin 的其他交互作用
常見問題
Can I take Ledipasvir-sofosbuvir with Phenytoin?
MediHelp rates the interaction as contraindicated. Ledipasvir-sofosbuvir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin is an inducer of P-gp and CYP enzymes and is expected to substantially reduce ledipasvir and sofosbuvir exposure. This can cause failure of hepatitis C therapy. Labeling advises against use together.
How serious is the interaction between Ledipasvir-sofosbuvir and Phenytoin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; replace phenytoin with a non-inducing antiepileptic before and during HCV treatment.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Rifampin. The full list is on the Ledipasvir-sofosbuvir page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
