藥物交互作用
Ledipasvir-sofosbuvir + St john's wort
嚴重程度: 禁忌併用
Ledipasvir-sofosbuvir and St john's wort: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
St John's wort is a potent inducer of intestinal P-glycoprotein and can markedly lower plasma concentrations of both ledipasvir and sofosbuvir. Reduced exposure may lead to loss of antiviral activity, failure to achieve sustained virologic response and possible resistance.
用白話說明這項交互作用的意義
Ledipasvir-sofosbuvir and St john's wort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Induction of intestinal P-glycoprotein (and other inducible pathways) by St John's wort reduces absorption and plasma exposure of ledipasvir and sofosbuvir.
處置方式
Do not combine; stop St John's wort before starting the hepatitis C regimen and choose an alternative if a herbal antidepressant is desired. Counsel patients to avoid herbal products during treatment.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ledipasvir-sofosbuvir 的其他交互作用
常見問題
Can I take Ledipasvir-sofosbuvir with St john's wort?
MediHelp rates the interaction as contraindicated. Ledipasvir-sofosbuvir and St john's wort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. St John's wort is a potent inducer of intestinal P-glycoprotein and can markedly lower plasma concentrations of both ledipasvir and sofosbuvir. Reduced exposure may lead to loss of antiviral activity, failure to achieve sustained virologic response and possible resistance.
How serious is the interaction between Ledipasvir-sofosbuvir and St john's wort?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop St John's wort before starting the hepatitis C regimen and choose an alternative if a herbal antidepressant is desired. Counsel patients to avoid herbal products during treatment.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
