藥物交互作用
Leucovorin + Phenytoin
嚴重程度: 中度
Leucovorin and Phenytoin: moderate interaction.
最後更新
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摘要
Folinic acid may reduce phenytoin levels and anticonvulsant effect, raising the risk of breakthrough seizures. Folate also has been reported to lower phenytoin concentrations.
用白話說明這項交互作用的意義
Leucovorin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leucovorin belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
為什麼會發生
Folate may increase phenytoin metabolism; a pro-convulsant effect has also been proposed.
處置方式
Monitor seizure control and phenytoin plasma concentrations during and after leucovorin treatment, adjusting the dose as needed.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Leucovorin 的其他交互作用
Phenytoin 的其他交互作用
常見問題
Can I take Leucovorin with Phenytoin?
MediHelp rates the interaction as moderate. Leucovorin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Folinic acid may reduce phenytoin levels and anticonvulsant effect, raising the risk of breakthrough seizures. Folate also has been reported to lower phenytoin concentrations.
How serious is the interaction between Leucovorin and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and phenytoin plasma concentrations during and after leucovorin treatment, adjusting the dose as needed.
What other medicines interact with Leucovorin?
MediHelp also lists interactions of Leucovorin with, for example, Capecitabine, Fluorouracil, Glucarpidase. The full list is on the Leucovorin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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